North American and Norwegian Chronic Wasting Disease Prions Exhibit Different Potential for Interspecies Transmission and Zoonotic Risk.
J Infect Dis
; 225(3): 542-551, 2022 02 01.
Article
em En
| MEDLINE
| ID: mdl-34302479
ABSTRACT
BACKGROUND:
Chronic wasting disease (CWD) is a rapidly spreading prion disorder affecting various species of wild and captive cervids. The risk that CWD poses to cohabiting animals or more importantly to humans is largely unknown.METHODS:
In this study, we investigated differences in the capacity of CWD isolates obtained from 6 different cervid species to induce prion conversion in vitro by protein misfolding cyclic amplification. We define and quantify spillover and zoonotic potential indices as the efficiency by which CWD prions sustain prion generation in vitro at expenses of normal prion proteins from various mammals and human, respectively.RESULTS:
Our data suggest that reindeer and red deer from Norway could be the most transmissible CWD prions to other mammals, whereas North American CWD prions were more prone to generate human prions in vitro.CONCLUSIONS:
Our results suggest that Norway and North American CWD prions correspond to different strains with distinct spillover and zoonotic potentials.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Príons
/
Cervos
/
Doença de Emaciação Crônica
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
País/Região como assunto:
America do norte
/
Europa
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article