Biopsy-Proven Lymphocytic Myocarditis With Heart Failure in a Middle-Aged Female Patient With Mixed Connective Tissue Disease.

Figliozzi, Stefano; Rizzo, Stefania; Cheng, Chun-Yan; Iliceto, Sabino; Basso, Cristina; Caforio, Alida L P; Marcolongo, Renzo

Biopsy-Proven Lymphocytic Myocarditis With Heart Failure in a Middle-Aged Female Patient With Mixed Connective Tissue Disease.

Figliozzi, Stefano; Rizzo, Stefania; Cheng, Chun-Yan; Iliceto, Sabino; Basso, Cristina; Caforio, Alida L P; Marcolongo, Renzo.

Afiliação

Figliozzi S; Division of Cardiology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Rizzo S; Cardiovascular Pathology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Italy.
Cheng CY; Division of Cardiology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Iliceto S; Division of Cardiology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Basso C; Cardiovascular Pathology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Italy.
Caforio ALP; Division of Cardiology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Marcolongo R; Hematology and Clinical Immunology, Department of Medicine, University of Padova, Padova, Italy.

JACC Case Rep ; 1(2): 171-174, 2019 Aug.

Article em En | MEDLINE | ID: mdl-34316778

ABSTRACT

ABSTRACT

A 56-year-old woman with mixed connective tissue disease, who was on maintenance immunosuppression, developed asymptomatic left ventricular dysfunction, ventricular arrhythmia, and high troponin I. Heart catheterization showed normal coronaries and biopsy-proven, virus-negative lymphocytic myocarditis. A biopsy-guided immunosuppression upgrade effectively treated autoimmune myocarditis, which resulted in ventricular function recovery, resolution of arrhythmia, and of troponin release. (Level of Difficulty Advanced.).

Palavras-chave

AHA, anti-heart autoantibodies; AIDA, anti-intercalated autoantibodies; CMR, cardiac magnetic resonance; EMB, endomyocardial biopsy; HRCT, high-resolution chest computed tomography; LVEF, left ventricle ejection fraction; MCTD, mixed connective tissue disease; MMF, mycophenolate mofetil; MTP, methylprednisolone; SID, systemic immune mediated disease; autoimmune; cardiomyopathy; chronic heart failure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article