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Thiocarbamoyl Fluoride Synthesis by Deconstructive Diversification of Arylated Tetrahydroisoquinolines.
Xu, Wentao; Liu, Fang; Li, Jiajun; Li, Muzi; Xie, Jin; Zhu, Chengjian.
Afiliação
  • Xu W; College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, China.
  • Liu F; State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
  • Li J; College of Chemistry, Nanchang University, Nanchang, Jiangxi 330031, China.
  • Li M; State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
  • Xie J; State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
  • Zhu C; State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
J Org Chem ; 86(17): 12443-12451, 2021 09 03.
Article em En | MEDLINE | ID: mdl-34324330
Deconstructive functionalization of cyclic amines can provide access to chemicals with diverse skeletons. We report the conversion of tertiary amines to thiocarbamoyl fluorides, a reaction enabled by photoredox catalysis and tolerating different functional groups while avoiding strong oxidants. A one-pot synthetic method from tertiary amines and AgF has been developed to get access to trifluoromethylamines. The synthesized thiocarbamoyl fluorides can be further transferred into esters.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetra-Hidroisoquinolinas / Fluoretos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tetra-Hidroisoquinolinas / Fluoretos Idioma: En Ano de publicação: 2021 Tipo de documento: Article