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Simultaneous inhibition of PFKFB3 and GLS1 selectively kills KRAS-transformed pancreatic cells.
Ozcan, Selahattin C; Mutlu, Aydan; Altunok, Tugba H; Gurpinar, Yunus; Sarioglu, Aybike; Guler, Sabire; Muchut, Robertino J; Iglesias, Alberto A; Celikler, Serap; Campbell, Paul M; Yalcin, Abdullah.
Afiliação
  • Ozcan SC; Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, 34450, Turkey.
  • Mutlu A; Department of General Biology, School of Arts & Science, Bursa Uludag University, Bursa, 16059, Turkey.
  • Altunok TH; Department of Biochemistry, School of Veterinary Medicine, Bursa Uludag University, Bursa, 16059, Turkey.
  • Gurpinar Y; Department of Biochemistry, School of Veterinary Medicine, Bursa Uludag University, Bursa, 16059, Turkey.
  • Sarioglu A; Department of Biochemistry, School of Veterinary Medicine, Bursa Uludag University, Bursa, 16059, Turkey.
  • Guler S; Department of Histology & Embryology, School of Veterinary Medicine, Bursa Uludag University, Bursa, 16059, Turkey.
  • Muchut RJ; Department of Molecular Enzymology, Coastal Agrobiotechnology Institute, National University of the Littoral, Santa Fe, 3000, Argentina.
  • Iglesias AA; Department of Molecular Enzymology, Coastal Agrobiotechnology Institute, National University of the Littoral, Santa Fe, 3000, Argentina.
  • Celikler S; Department of General Biology, School of Arts & Science, Bursa Uludag University, Bursa, 16059, Turkey.
  • Campbell PM; The Marvin and Concetta Greenberg Pancreatic Cancer Institute, Cancer Signaling & Epigenetics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Yalcin A; Department of Biochemistry, School of Veterinary Medicine, Bursa Uludag University, Bursa, 16059, Turkey. Electronic address: ayalcin@uludag.edu.tr.
Biochem Biophys Res Commun ; 571: 118-124, 2021 09 24.
Article em En | MEDLINE | ID: mdl-34325126

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Tiadiazóis / Proteínas Proto-Oncogênicas p21(ras) / Fosfofrutoquinase-2 / Benzenoacetamidas / Glutaminase / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Tiadiazóis / Proteínas Proto-Oncogênicas p21(ras) / Fosfofrutoquinase-2 / Benzenoacetamidas / Glutaminase / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article