Impact of a vancomycin loading dose on the achievement of target vancomycin exposure in the first 24 h and on the accompanying risk of nephrotoxicity in critically ill patients.
J Antimicrob Chemother
; 76(11): 2941-2949, 2021 10 11.
Article
em En
| MEDLINE
| ID: mdl-34337660
ABSTRACT
BACKGROUND:
The advocated pharmacokinetic/pharmacodynamic (PK/PD) target for vancomycin, AUC/MICâ≥â400 mg·h/L, may not be reached with a conventional fixed starting dose of 1000 mg in critically ill patients, but increasing the dose may cause nephrotoxicity.OBJECTIVES:
To evaluate the effect of a weight-based loading dose of 25 mg/kg vancomycin on PK/PD target attainment in the first 24 h (AUC0-24) in critically ill patients and to evaluate whether this increases the risk of acute kidney injury (AKI). PATIENTS ANDMETHODS:
A prospective observational before/after study was performed in ICU patients, comparing the percentage of vancomycin courses with AUC0-24â≥â400 mg·h/L and the incidence of AKI, defined as worsening of the risk, injury, failure, loss of kidney function and end-stage kidney disease (RIFLE) score. The conventional dose group received 1000 mg of vancomycin as initial dose; the loading dose group received a weight-based loading dose of 25 mg/kg. A population PK model developed using non-linear mixed-effects modelling was used to estimate AUC0-24 in all patients.RESULTS:
One hundred and four courses from 82 patients were included. With a loading dose, the percentage of courses achieving AUC0-24â≥â400 mg·h/L increased significantly from 53.8% to 88.0% (Pâ=â0.0006). The percentage of patients with new-onset AKI was not significantly higher when receiving a 25 mg/kg loading dose (28.6% versus 37.8%; Pâ=â0.48). However, the risk of AKI was significantly higher in patients achieving AUC0-24â>â400 mg·h/L compared with patients achieving AUCâ<â400 mg·h/L (39.0% versus 14.8%; Pâ=â0.031).CONCLUSIONS:
A weight-based loading dose of 25 mg/kg vancomycin led to significantly more patients achieving AUC0-24â≥â400 mg·h/L without increased risk of AKI. However, some harm cannot be ruled out since higher exposure was associated with increased risk of AKI.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vancomicina
/
Injúria Renal Aguda
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article