Retinal nerve fibre layer and ganglion cell layer changes in children who recovered from COVID-19: a cohort study.
Arch Dis Child
; 107(2): 175-179, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34340983
ABSTRACT
OBJECTIVE:
To investigate the optic nerve and macular parameters of children who recovered from COVID-19 compared with healthy children using optical coherence tomography (OCT).DESIGN:
Cohort study.SETTING:
Hospital Clinico San Carlos, Madrid. PATIENTS Children between 6 and 18 years old who recovered from COVID-19 with laboratory-confirmed SARS-CoV-2 infection and historical controls were included.INTERVENTIONS:
All patients underwent an ophthalmological examination, including macular and optic nerve OCT. Demographic data, medical history and COVID-19 symptoms were noted. MAIN OUTCOMEMEASURES:
Peripapillary retinal nerve fibre layer thickness, macular retinal nerve fibre layer thickness, macular ganglion cell layer thickness and retinal thickness.RESULTS:
90 patients were included 29 children who recovered from COVID-19 and 61 controls. Patients with COVID-19 presented an increase in global peripapillary retinal nerve fibre layer thickness (mean difference 7.7; 95% CI 3.4 to 12.1), temporal superior (mean difference 11.0; 95% CI 3.3 to 18.6), temporal inferior (mean difference 15.6; 95% CI 6.5 to 24.7) and nasal (mean difference 9.8; 95% CI 2.9 to 16.7) sectors. Macular retinal nerve fibre layer analysis showed decreased thickness in the nasal outer (p=0.011) and temporal inner (p=0.036) sectors in patients with COVID-19, while macular ganglion cell layer thickness increased in these sectors (p=0.001 and p=0.015, respectively). No differences in retinal thickness were noted.CONCLUSIONS:
Children with recent history of COVID-19 present significant changes in peripapillary and macular OCT analyses.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nervo Óptico
/
Células Ganglionares da Retina
/
COVID-19
/
Fibras Nervosas
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
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Child
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Humans
/
Male
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article