Cellular context shapes cyclic nucleotide signaling in neurons through multiple levels of integration.
J Neurosci Methods
; 362: 109305, 2021 10 01.
Article
em En
| MEDLINE
| ID: mdl-34343574
ABSTRACT
Intracellular signaling with cyclic nucleotides are ubiquitous signaling pathways, yet the dynamics of these signals profoundly differ in different cell types. Biosensor imaging experiments, by providing direct measurements in intact cellular environment, reveal which receptors are activated by neuromodulators and how the coincidence of different neuromodulators is integrated at various levels in the signaling cascade. Phosphodiesterases appear as one important determinant of cross-talk between different signaling pathways. Finally, analysis of signal dynamics reveal that striatal medium-sized spiny neuron obey a different logic than other brain regions such as cortex, probably in relation with the function of this brain region which efficiently detects transient dopamine.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
AMP Cíclico
/
Nucleotídeos Cíclicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article