Blocking MCT4 SUMOylation inhibits the growth of breast cancer cells.

Hu, Xiao; Liu, Zhanzhao; Duan, Xianxian; Han, Xiao; Yuan, Mengci; Liu, Lingyan; Xia, Xiaojun; Li, Ning; Qin, Junfang; Wang, Yue

Hu, Xiao; Liu, Zhanzhao; Duan, Xianxian; Han, Xiao; Yuan, Mengci; Liu, Lingyan; Xia, Xiaojun; Li, Ning; Qin, Junfang; Wang, Yue.

Afiliação

Hu X; Department of Biochemistry and Molecular Biology, State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China.
Liu Z; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.
Duan X; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.
Han X; Department of Biochemistry and Molecular Biology, State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China.
Yuan M; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.
Liu L; Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Xia X; Department of Biochemistry and Molecular Biology, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou, China.
Li N; Institue of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Qin J; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.
Wang Y; Department of Immunology, School of Medicine, Nankai University, Tianjin, China.

Mol Carcinog ; 60(10): 702-714, 2021 10.

Article em En | MEDLINE | ID: mdl-34347919

Assuntos

Neoplasias da Mama/metabolismo; Transportadores de Ácidos Monocarboxílicos/metabolismo; Proteínas Musculares/metabolismo; Expressão Gênica; Humanos; Transportadores de Ácidos Monocarboxílicos/genética; Proteínas Musculares/genética; Mutação; Processamento de Proteína Pós-Traducional; Proteólise; Sumoilação/efeitos dos fármacos; Ubiquitina-Proteína Ligases/metabolismo; Ubiquitinação

Palavras-chave

SUMOylation; breast cancer (BC); monocarboxylate transporter 4 (MCT4); posttranslational modifications (PTMs); ubiquitination

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transportadores de Ácidos Monocarboxílicos / Proteínas Musculares Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google