Calyhedins I-VI: Resin glycosides from the rhizomes of Calystegia hederacea.
Phytochemistry
; 190: 112888, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34358900
ABSTRACT
Six previously undescribed resin glycosides, calyhedins I-VI, were isolated from the rhizomes of Calystegia hederacea Wall., which are the first genuine resin glycosides isolated from C. hederacea. The structures of calyhedins I-VI were determined based on spectroscopic data and chemical evidence. All the compounds have macrolactone structures (jalapins), and their sugar moieties were partially acylated by five organic acids. Calyhedins I, II-V, and VI have 27-, 28-, and 23-membered rings, respectively, and calyhedins IV-VI are the first jalapins with a sugar chain consisting of seven monosaccharides. Additionally, the cytotoxic activity of calyhedins II and III toward HL-60 human promyelocytic leukemia cells was evaluated. Both compounds demonstrated almost the same activity as the positive control, cisplatin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Calystegia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article