8-, 9-, and 11-Aryloxy Dimeric Aporphines and Their Pharmacological Activities.
Molecules
; 26(15)2021 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-34361671
ABSTRACT
Aporphines, a major group of aporphinoid alkaloids, exhibit interesting and diverse pharmacological activities. A set of dimeric aporphines with an aryloxy group at C8, C9, and C11 have been isolated from six genera and shown to elicit various biological activities such as antitumor, antimalarial, antimicrobial, antiplatelet aggregation, antifibrotic, immunosuppressive, and vasorelaxant properties. In this review, the nomenclature, chemical structures, botanical sources, pharmacological activities, and synthetic approaches of this set of dimeric alkaloids are presented.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aporfinas
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Vasodilatadores
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Inibidores da Agregação Plaquetária
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Extratos Vegetais
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Dimerização
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Imunossupressores
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Anti-Infecciosos
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Antineoplásicos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article