<i>N<sup>6</sup></i> -methyladenosine-Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression.

Deng, Junge; Zhang, Jialiang; Ye, Ying; Liu, Kaijing; Zeng, Lingxing; Huang, Jingyi; Pan, Ling; Li, Mei; Bai, Ruihong; Zhuang, Lisha; Huang, Xudong; Wu, Guandi; Wei, Lusheng; Zheng, Yanfen; Su, Jiachun; Zhang, Shaoping; Chen, Rufu; Lin, Dongxin; Zheng, Jian

N⁶ -methyladenosine-Mediated Upregulation of WTAPP1 Promotes WTAP Translation and Wnt Signaling to Facilitate Pancreatic Cancer Progression.

Deng, Junge; Zhang, Jialiang; Ye, Ying; Liu, Kaijing; Zeng, Lingxing; Huang, Jingyi; Pan, Ling; Li, Mei; Bai, Ruihong; Zhuang, Lisha; Huang, Xudong; Wu, Guandi; Wei, Lusheng; Zheng, Yanfen; Su, Jiachun; Zhang, Shaoping; Chen, Rufu; Lin, Dongxin; Zheng, Jian.

Afiliação

Deng J; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhang J; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Ye Y; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Liu K; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zeng L; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Huang J; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Pan L; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Li M; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Bai R; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhuang L; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Huang X; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Wu G; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Wei L; Department of Pancreaticobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Zheng Y; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Su J; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhang S; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China.
Chen R; Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China.
Lin D; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, Sun Yat-sen University Cancer Center, Guangzhou, China. zhengjian@sysucc.org.cn lindx@sysucc.org.cn.
Zheng J; Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Cancer Res ; 81(20): 5268-5283, 2021 10 15.

Article em En | MEDLINE | ID: mdl-34362795

Assuntos

Adenosina/análogos & derivados; Carcinoma Ductal Pancreático/patologia; Proteínas de Ciclo Celular/metabolismo; Neoplasias Pancreáticas/patologia; Biossíntese de Proteínas; Fatores de Processamento de RNA/metabolismo; RNA Longo não Codificante/genética; Via de Sinalização Wnt; Adenosina/química; Animais; Apoptose; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/metabolismo; Proteínas de Ciclo Celular/genética; Proliferação de Células; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Prognóstico; Fatores de Processamento de RNA/genética; Taxa de Sobrevida; Ativação Transcricional; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Biossíntese de Proteínas / Adenosina / Proteínas de Ciclo Celular / Carcinoma Ductal Pancreático / Via de Sinalização Wnt / RNA Longo não Codificante / Fatores de Processamento de RNA Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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