Low Levels of Serum Sclerostin in Adult Patients With Tumor-Induced Osteomalacia Compared With X-linked Hypophosphatemia.
J Clin Endocrinol Metab
; 107(1): e361-e371, 2022 01 01.
Article
em En
| MEDLINE
| ID: mdl-34363479
ABSTRACT
CONTEXT Sclerostin inhibits Wnt-ß-catenin signaling, regulating bone formation. Circulating sclerostin was reported to be elevated in X-linked hypophosphatemia (XLH) patients, and sclerostin antibody (Scl-Ab) increased bone mass and normalized circulating phosphate in Hyp mice. However, circulating sclerostin levels in patients with acquired hypophosphatemia due to tumor-induced osteomalacia (TIO) are rarely reported. OBJECTIVE:
This study was designed to evaluate serum sclerostin levels in TIO patients compared with age- and sex-matched healthy controls and XLH patients to analyze correlations with bone mineral density (BMD) and laboratory parameters.METHODS:
This cross-sectional study determined serum sclerostin levels in 190 individuals, comprising 83 adult TIO patients, 83 adult healthy controls and 24 adult XLH patients.RESULTS:
TIO patients (43 male, 40 female) aged 44.3â ±â 8.7 (mean ± SD) years had lower levels of circulating sclerostin than controls (94.2â ±â 45.8 vs 108.4â ±â 42.3 pg/mL, Pâ =â 0.01), adjusted for age, gender, BMI, and diabetes rate. Sclerostin levels were positively associated with age (r =â 0.238, Pâ =â 0.030). Male patients had higher sclerostin than female patients (104.7â ±â 47.3 vs 83.0â ±â 41.8 pg/mL, Pâ =â 0.014). Sclerostin levels were positively associated with L1-4 BMD (r =â 0.255, Pâ =â 0.028), femoral neck BMD (r =â 0.242, Pâ =â 0.039), and serum calcium (r =â 0.231, Pâ =â 0.043). Comparison of sclerostin levels in TIO patients (nâ =â 24, age 35.9â ±â 7.3 years) vs XLH patients vs healthy controls revealed significant differences (respectively, 68.4â ±â 31.3, 132.0â ±â 68.8, and 98.6â ±â 41.1 pg/mL, Pâ <â 0.001).CONCLUSION:
Circulating sclerostin was decreased in TIO patients but increased in XLH patients, possibly due to histological abnormality and bone mass.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteomalacia
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Síndromes Paraneoplásicas
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Proteínas Adaptadoras de Transdução de Sinal
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Raquitismo Hipofosfatêmico Familiar
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article