Your browser doesn't support javascript.
loading
Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation.
Orozco, Carolina T; Edgeworth, Matthew J; Devine, Paul W A; Hines, Alistair R; Cornwell, Owen; Thompson, Christopher; Wang, Xiangyang; Phillips, Jonathan J; Ravn, Peter; Jackson, Sophie E; Bond, Nicholas J.
Afiliação
  • Orozco CT; Yusuf Hamied Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom.
  • Edgeworth MJ; Analytical Sciences, Biopharmaceutical Development, R&D, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
  • Devine PWA; Analytical Sciences, Biopharmaceutical Development, R&D, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
  • Hines AR; Analytical Sciences, Biopharmaceutical Development, R&D, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
  • Cornwell O; Analytical Sciences, Biopharmaceutical Development, R&D, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
  • Thompson C; Purification Process Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Gaithersburg, Maryland 20878, United States.
  • Wang X; Analytical Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Gaithersburg, Maryland 20878, United States.
  • Phillips JJ; Living Systems Institute, Department of Biosciences, University of Exeter, EX4 4QD Exeter, United Kingdom.
  • Ravn P; Antibody Discovery and Protein Engineering, R&D, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
  • Jackson SE; Yusuf Hamied Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom.
  • Bond NJ; Analytical Sciences, Biopharmaceutical Development, R&D, AstraZeneca, CB21 6GH Cambridge, United Kingdom.
Bioconjug Chem ; 32(8): 1834-1844, 2021 08 18.
Article em En | MEDLINE | ID: mdl-34369158
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Sulfidrila / Imunoconjugados / Especificidade de Anticorpos / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Sulfidrila / Imunoconjugados / Especificidade de Anticorpos / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article