High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide.
Science
; 373(6556): 813-818, 2021 08 13.
Article
em En
| MEDLINE
| ID: mdl-34385401
ABSTRACT
A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to a high-fat diet escalates Escherichia coli choline catabolism by altering intestinal epithelial physiology. A high-fat diet impaired the bioenergetics of mitochondria in the colonic epithelium to increase the luminal bioavailability of oxygen and nitrate, thereby intensifying respiration-dependent choline catabolism of E. coli In turn, E. coli choline catabolism increased levels of circulating trimethlamine N-oxide, which is a potentially harmful metabolite generated by gut microbiota.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colo
/
Escherichia coli
/
Dieta Hiperlipídica
/
Mucosa Intestinal
/
Metilaminas
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article