Your browser doesn't support javascript.
loading
Topical emollient therapy with sunflower seed oil alters the skin microbiota of young children with severe acute malnutrition in Bangladesh: A randomised, controlled study.
Fischer, Natalie; Darmstadt, Gary L; Shahunja, K M; Crowther, Jonathan M; Kendall, Lindsay; Gibson, Rachel A; Ahmed, Tahmeed; Relman, David A.
Afiliação
  • Fischer N; Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Darmstadt GL; Prematurity Research Center, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
  • Shahunja KM; Nutrition and Clinical Services Division, International Centre for Diarroheal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Crowther JM; JMC Scientific Consulting Ltd, Egham, Surrey, UK.
  • Kendall L; GlaxoSmithKline R&D, Global Health Catalyst, Stevenage, UK.
  • Gibson RA; GlaxoSmithKline R&D, Global Health Catalyst, Stevenage, UK.
  • Ahmed T; Nutrition and Clinical Services Division, International Centre for Diarroheal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh.
  • Relman DA; Division of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
J Glob Health ; 11: 04047, 2021.
Article em En | MEDLINE | ID: mdl-34386216
ABSTRACT

BACKGROUND:

Topical emollient therapy with sunflower seed oil (SSO) reduces risk of sepsis and mortality in very preterm infants in low- or middle-income countries (LMICs). Proposed mechanisms include modulation of skin and possibly gut barrier function. The skin and gut microbiota play important roles in regulating barrier function, but the effects of emollient therapy on these microbiotas are poorly understood.

METHODS:

We characterised microbiota structure and diversity with 16S rRNA gene amplicon sequence data and ecological statistics in 20 children with severe acute malnutrition (SAM) aged 2-24 months, at four skin sites and in stool, during a randomised, controlled trial of emollient therapy with SSO in Bangladesh. Microbes associated with therapy were identified with tree-based sparse discriminant analysis.

RESULTS:

The skin microbiota of Bangladeshi children with SAM was highly diverse and displayed significant variation in structure as a function of physical distance between sites. Microbiota structure differed between the study groups (P = 0.005), was more diverse in emollient-treated subjects-including on the forehead which did not receive direct treatment-and changed with each day (P = 0.005) at all skin sites. Overall, Prevotellaceae were the most differentially affected by emollient treatment; several genera within this family became more abundant in the emollient group than in the controls across several skin sites. Gut microbiota structure was associated with sample day (P = 0.045) and subject age (P = 0.045), but was not significantly affected by emollient treatment (P = 0.060).

CONCLUSIONS:

Emollient therapy altered the skin microbiota in a consistent and temporally coherent manner. We speculate that therapy with SSO enhances skin barrier function in part through alterations in the microbiota, and through systemic mechanisms. Strategies to strengthen skin and gut barrier function in populations at risk, such as children in LMICs like Bangladesh, might include deliberate manipulation of their skin microbiota. TRIAL REGISTRATION ClinicalTrials.gov NCT02616289.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbiota / Desnutrição Aguda Grave Tipo de estudo: Clinical_trials Limite: Child / Child, preschool / Humans / Infant / Newborn País/Região como assunto: Asia Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microbiota / Desnutrição Aguda Grave Tipo de estudo: Clinical_trials Limite: Child / Child, preschool / Humans / Infant / Newborn País/Região como assunto: Asia Idioma: En Ano de publicação: 2021 Tipo de documento: Article