Targeting interleukin-ß by plant-derived natural products: Implications for the treatment of atherosclerotic cardiovascular disease.
Phytother Res
; 35(10): 5596-5622, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34390063
ABSTRACT
Inflammation is the main contributing factor to atheroma formation in atherosclerosis. Interleukin-1 beta (IL-1ß) is an inflammatory mediator found in endothelial cells and resident leukocytes. Canakinumab is a selective monoclonal antibody against IL-1ß which attenuates inflammation and concurrently precipitates fatal infections and sepsis. Natural products derived from medicinal plants, herbal remedy and functional foods are widely used nowadays. Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1ß suppression. In this review, we tried to document findings that used medicinal plants and plant-based natural products for treating atherosclerosis and its related diseases through the suppression of IL-1ß.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Doenças Cardiovasculares
/
Aterosclerose
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article