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Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia.
Thastrup, Maria; Marquart, Hanne Vibeke; Levinsen, Mette; Modvig, Signe; Abrahamsson, Jonas; Albertsen, Birgitte Klug; Frost, Britt-Marie; Harila-Saari, Arja; Pesola, Jouni; Ulvmoen, Aina; Wojcik, Dorota Malgorzata; Taskinen, Mervi; Hoffmann, Marianne; Lausen, Birgitte; Schmiegelow, Kjeld.
Afiliação
  • Thastrup M; Department of Paediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Marquart HV; Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Levinsen M; Department of Paediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Modvig S; Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Abrahamsson J; Department of Paediatrics, Institution of Clinical Sciences, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Albertsen BK; Children and Adolescent Health, Aarhus University Hospital, Aarhus, Denmark.
  • Frost BM; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
  • Harila-Saari A; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
  • Pesola J; Paediatric Haematology and Oncology Unit, Kuopio University Hospital, Kuopio, Finland.
  • Ulvmoen A; Department of Paediatrics, Oslo University Hospital, Oslo, Norway.
  • Wojcik DM; Children's Clinic, Haukeland University Hospital, Bergen, Norway.
  • Taskinen M; Division of Paediatric Haematology, Oncology and Stem Cell Transplantation, Children and Adolescents, Helsinki University Hospital, Helsinki, Finland.
  • Hoffmann M; Department of Paediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Lausen B; Department of Paediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Schmiegelow K; Department of Paediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Br J Haematol ; 195(1): 119-122, 2021 10.
Article em En | MEDLINE | ID: mdl-34396501
ABSTRACT
Infants with acute lymphoblastic leukaemia (ALL) have a high frequency of central nervous system (CNS) involvement. Flow cytometric analysis of cerebrospinal fluid (CSF) was recently demonstrated to be a sensitive method for detecting CNS involvement in childhood ALL. In the present study, CSF from 14 infants was collected at routine lumbar punctures and analysed by multicolour flow cytometry. At initial diagnosis, leukaemic blasts were detected in CSF by flow cytometry in 11 patients (78·6%) compared to seven patients (50%) by cytospin. Larger studies are needed to determine if CSF flow cytometry has prognostic value in infant ALL.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Líquido Cefalorraquidiano / Infiltração Leucêmica / Leucemia-Linfoma Linfoblástico de Células Precursoras / Citometria de Fluxo Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male / Newborn Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Líquido Cefalorraquidiano / Infiltração Leucêmica / Leucemia-Linfoma Linfoblástico de Células Precursoras / Citometria de Fluxo Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Infant / Male / Newborn Idioma: En Ano de publicação: 2021 Tipo de documento: Article