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Parabacteroides distasonis induces depressive-like behavior in a mouse model of Crohn's disease.
Gomez-Nguyen, Adrian; Basson, Abigail R; Dark-Fleury, Luc; Hsu, Kristen; Osme, Abdullah; Menghini, Paola; Pizarro, Theresa T; Cominelli, Fabio.
Afiliação
  • Gomez-Nguyen A; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
  • Basson AR; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
  • Dark-Fleury L; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
  • Hsu K; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
  • Osme A; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
  • Menghini P; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
  • Pizarro TT; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Pathology, Case Western Reserve University School of Medicine
  • Cominelli F; Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Department of Pathology, Case Western Reserve University School of Medicine
Brain Behav Immun ; 98: 245-250, 2021 11.
Article em En | MEDLINE | ID: mdl-34403735
ABSTRACT
Patients with inflammatory bowel disease (IBD) are particularly susceptible to behavioral diagnoses, and the microbiome has been repeatedly implicated in the pathogenesis of IBD. The intestinal microbiome's ability to affect behavior has become increasingly recognized and studied. The so-called 'psychobiome' has been linked to a plethora of neurological and psychological diagnoses, including autism and Parkinson's disease. Despite the ability of many bacterial species within the human intestinal microbiome to synthesize neurotransmitters, it has never been previously reported that a single bacterial species is sufficient to induce depression. Here, we demonstrate that our mouse model of Crohn's disease (CD)-like ileitis, the SAMP1/YitFc (SAMP1), does not exhibit baseline behavioral abnormalities. By comparison, SAMP6 mice develop depressive-like behavior that is associated with a rise in the GABA-producing bacterial genus Parabacteroides. We finally demonstrate that administration of Parabacteroides distasonis into our SAMP1 mice induces depressive-like behavior. Colonization with P. distasonis was not associated with increased intestinal inflammation or alterations in other measures of behavior. The intestinal environment of CD may be particularly conducive to colonization with P. distasonis and subsequent induction of depressive-like behavior. To our knowledge, this is the first report of a bacterial species specifically inducing depressive-like behavior.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Crohn / Ileíte Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Crohn / Ileíte Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article