Identification of phenylcarbamoylazinane-1,3,4-oxadiazole amides as lipoxygenase inhibitors with expression analysis and in silico studies.

Bashir, Bushra; Shahid, Wardah; Ashraf, Muhammad; Saleem, Muhammad; Muzaffar, Saima; Imran, Muhammad; Amjad, Hira; Bhattarai, Keshab; Riaz, Naheed

Bashir, Bushra; Shahid, Wardah; Ashraf, Muhammad; Saleem, Muhammad; Muzaffar, Saima; Imran, Muhammad; Amjad, Hira; Bhattarai, Keshab; Riaz, Naheed.

Afiliação

Bashir B; Institute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Shahid W; Institute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Ashraf M; Institute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan. Electronic address: dr.m.ashraf@gmail.com.
Saleem M; Institute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Aziz-Ur-Rehman; Department of Chemistry, Government College University Lahore, Lahore 54000, Pakistan.
Muzaffar S; Institute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Imran M; Institute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Amjad H; Department of Chemistry, Government College University Lahore, Lahore 54000, Pakistan.
Bhattarai K; Department of Pharmaceutical Biology, Auf der Morgenstelle 8, 72076, University of Tuebingen, Tuebingen, Germany.
Riaz N; Institute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan. Electronic address: nrch322@iub.edu.pk.

Bioorg Chem ; 115: 105243, 2021 10.

Article em En | MEDLINE | ID: mdl-34403937

Assuntos

Amidas/farmacologia; Araquidonato 15-Lipoxigenase/metabolismo; Inibidores de Lipoxigenase/farmacologia; Oxidiazóis/farmacologia; Amidas/síntese química; Amidas/química; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Humanos; Leucócitos Mononucleares/efeitos dos fármacos; Inibidores de Lipoxigenase/síntese química; Inibidores de Lipoxigenase/química; Modelos Moleculares; Estrutura Molecular; Oxidiazóis/síntese química; Oxidiazóis/química; Relação Estrutura-Atividade

Palavras-chave

ADME studies; Azinane-oxadiazoles; Expression analysis; In silico studies; Lipoxygenase inhibition; MTT assay; Synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxidiazóis / Araquidonato 15-Lipoxigenase / Inibidores de Lipoxigenase / Amidas Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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