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Effect of racial background on motor cortical function as measured by threshold tracking transcranial magnetic stimulation.
Suzuki, Yo-Ichi; Ma, Yan; Shibuya, Kazumoto; Misawa, Sonoko; Suichi, Tomoki; Tsuneyama, Atsuko; Nakamura, Keigo; Matamala, José Manuel; Dharmadasa, Thanuja; Vucic, Steve; Fan, Dongsheng; Kiernan, Matthew C; Kuwabara, Satoshi.
Afiliação
  • Suzuki YI; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Ma Y; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
  • Shibuya K; Department of Neurology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
  • Misawa S; Department of Neurology, Peking University Third Hospital, Beijing, China.
  • Suichi T; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Tsuneyama A; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
  • Nakamura K; Department of Neurology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
  • Matamala JM; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Dharmadasa T; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Vucic S; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Fan D; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Kiernan MC; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.
  • Kuwabara S; Department of Neurology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
J Neurophysiol ; 126(3): 840-844, 2021 Sep 01.
Article em En | MEDLINE | ID: mdl-34406906
ABSTRACT
A previous study using traditional paired-pulse TMS methods (amplitude-tracking) has reported differences in resting motor threshold (RMT) and short-interval intracortical inhibition (SICI) between healthy subjects of Caucasian and Han Chinese backgrounds, probably due to differences in the skull shape. The amplitude-tracking method delivers stimuli with constant intensity and causes substantial variabilities in motor-evoked potential amplitudes. To overcome this variability, threshold tracking transcranial magnetic stimulation (TT-TMS) has been developed. The present study aimed to investigate whether racial differences in motor cortical function exist, using TT-TMS. A total of 83 healthy volunteers (30 Caucasians, 25 Han Chinese, and 28 Japanese) were included in the present series. In TT-TMS and nerve conduction studies, electrodes were placed on the dominant limb, with measures recorded from the abductor pollicis brevis muscle. Stimulations were delivered with a circular coil, directly above the primary motor cortex. There were no significant differences at all the SICI intervals between races. Similarly, there were no significant differences in other measures of excitability including mean RMT, intracortical facilitation, and cortical silent period. Contrary to traditional amplitude-tracking TMS, motor cortical excitability and thereby motor cortical function is minimally influenced by racial differences when measured by TT-TMS. Recent studies have disclosed that SICI measured by TT-TMS differentiates amyotrophic lateral sclerosis (ALS) from ALS mimic disorders, with high sensitivity and specificity, in Caucasians. This study suggested that TT-TMS can be applied for the ALS diagnosis in Asian patients, as well as Caucasians.NEW & NOTEWORTHY Threshold tracking transcranial magnetic stimulation (TT-TMS) was applied for Caucasians, Han Chinese, and Japanese. No significant differences were found in TMS excitability indexes among races. Recent studies have disclosed that TT-TMS indexes differentiate amyotrophic lateral sclerosis (ALS) from ALS mimic disorders, with high sensitivity and specificity, in Caucasians. This study suggested that TT-TMS can be applied for the ALS diagnosis in Asian patients, as well as Caucasians.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Potencial Evocado Motor / Estimulação Magnética Transcraniana / Esclerose Lateral Amiotrófica / Córtex Motor Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Potencial Evocado Motor / Estimulação Magnética Transcraniana / Esclerose Lateral Amiotrófica / Córtex Motor Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article