A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.

Villemure, Elisia; Terrett, Jack A; Larouche-Gauthier, Robin; Déry, Martin; Chen, Huifen; Reese, Rebecca M; Shields, Shannon D; Chen, Jun; Magnuson, Steven; Volgraf, Matthew

Villemure, Elisia; Terrett, Jack A; Larouche-Gauthier, Robin; Déry, Martin; Chen, Huifen; Reese, Rebecca M; Shields, Shannon D; Chen, Jun; Magnuson, Steven; Volgraf, Matthew.

Afiliação

Villemure E; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Terrett JA; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Larouche-Gauthier R; Paraza Pharma, Inc. 2525 Avenue Marie-Curie, Montréal, Québec H4S 2E1, Canada.
Déry M; Paraza Pharma, Inc. 2525 Avenue Marie-Curie, Montréal, Québec H4S 2E1, Canada.
Chen H; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Reese RM; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Shields SD; Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Chen J; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Magnuson S; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Volgraf M; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

ACS Med Chem Lett ; 12(8): 1230-1237, 2021 Aug 12.

Article em En | MEDLINE | ID: mdl-34413952

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article