Altered metabolic pathways elucidated via untargeted in vivo toxicometabolomics in rat urine and plasma samples collected after controlled application of a human equivalent amphetamine dose.

Hemmer, Selina; Wagmann, Lea; Meyer, Markus R

Hemmer, Selina; Wagmann, Lea; Meyer, Markus R.

Afiliação

Hemmer S; Department of Experimental and Clinical Toxicology, Center for Molecular Signaling (PZMS), Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421, Homburg, Germany.
Wagmann L; Department of Experimental and Clinical Toxicology, Center for Molecular Signaling (PZMS), Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421, Homburg, Germany.
Meyer MR; Department of Experimental and Clinical Toxicology, Center for Molecular Signaling (PZMS), Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421, Homburg, Germany. markus.meyer@uks.eu.

Arch Toxicol ; 95(10): 3223-3234, 2021 10.

Article em En | MEDLINE | ID: mdl-34414480

Assuntos

Anfetamina/toxicidade; Estimulantes do Sistema Nervoso Central/toxicidade; Metaboloma/efeitos dos fármacos; Metabolômica; Aminoácidos/sangue; Anfetamina/metabolismo; Animais; Biomarcadores/metabolismo; Estimulantes do Sistema Nervoso Central/metabolismo; Cromatografia Líquida; Regulação para Baixo/efeitos dos fármacos; Masculino; Espectrometria de Massas; Análise de Componente Principal; Ratos; Ratos Wistar

Palavras-chave

Amphetamine; LC-HRMS/MS; Toxicometabolomics; Untargeted metabolomics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Metaboloma / Metabolômica / Anfetamina / Estimulantes do Sistema Nervoso Central Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google