Distinct pro-inflammatory properties of myeloid cell-derived apolipoprotein E2 and E4 in atherosclerosis promotion.

Igel, Emily; Haller, April; Wolfkiel, Patrick R; Orr-Asman, Melissa; Jaeschke, Anja; Hui, David Y

Igel, Emily; Haller, April; Wolfkiel, Patrick R; Orr-Asman, Melissa; Jaeschke, Anja; Hui, David Y.

Afiliação

Igel E; Department of Pathology and Laboratory Medicine, Metabolic Diseases Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Haller A; Department of Pathology and Laboratory Medicine, Metabolic Diseases Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Wolfkiel PR; Department of Pathology and Laboratory Medicine, Metabolic Diseases Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Orr-Asman M; Department of Pathology and Laboratory Medicine, Metabolic Diseases Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jaeschke A; Department of Pathology and Laboratory Medicine, Metabolic Diseases Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Hui DY; Department of Pathology and Laboratory Medicine, Metabolic Diseases Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. Electronic address: huidy@ucmail.uc.edu.

J Biol Chem ; 297(3): 101106, 2021 09.

Article em En | MEDLINE | ID: mdl-34425108

Assuntos

Apolipoproteína E2/metabolismo; Apolipoproteína E4/metabolismo; Aterosclerose/genética; Animais; Apolipoproteína E2/genética; Apolipoproteína E3/metabolismo; Apolipoproteína E4/genética; Apolipoproteínas E/metabolismo; Aterosclerose/metabolismo; Feminino; Humanos; Inflamação; Lipoproteínas/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Células Mieloides/metabolismo; Transdução de Sinais

Palavras-chave

ApoE polymorphism; atherosclerosis; bone marrow transplant; cholesterol efflux; inflammasome; inflammation; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aterosclerose / Apolipoproteína E2 / Apolipoproteína E4 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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