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Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of ß-Hydroxyketones.
Hilker, Simon; Posevins, Daniels; Unelius, C Rikard; Bäckvall, Jan-E.
Afiliação
  • Hilker S; Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
  • Posevins D; Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
  • Unelius CR; Department of Chemistry and Biomedical Science, Linnaeus University, 39231, Kalmar, Sweden.
  • Bäckvall JE; Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691, Stockholm, Sweden.
Chemistry ; 27(63): 15623-15627, 2021 Nov 11.
Article em En | MEDLINE | ID: mdl-34428339
Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α-substituted ß-hydroxyketones (ß-HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α-substituted ß-oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rutênio Idioma: En Ano de publicação: 2021 Tipo de documento: Article