Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of ß-Hydroxyketones.
Chemistry
; 27(63): 15623-15627, 2021 Nov 11.
Article
em En
| MEDLINE
| ID: mdl-34428339
Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α-substituted ß-hydroxyketones (ß-HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α-substituted ß-oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios.
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01-internacional
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MEDLINE
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Rutênio
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article