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Dysregulation of microRNAs in metal-induced angiogenesis and carcinogenesis.
Wang, Lin; Liu, Ling-Zhi; Jiang, Bing-Hua.
Afiliação
  • Wang L; Academy of Medical Science, Zhengzhou University, Zhengzhou, 450000, China; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, United States.
  • Liu LZ; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, United States. Electronic address: ling-zhi.liu@jefferson.edu.
  • Jiang BH; Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, United States. Electronic address: Binghua.jiang@jefferson.edu.
Semin Cancer Biol ; 76: 279-286, 2021 11.
Article em En | MEDLINE | ID: mdl-34428550
MicroRNAs (miRNAs) are small endogenous non-coding RNAs that regulate cancer initiation, development, angiogenesis, and therapeutic resistance. Metal exposure widely occurs through air, water, soil, food, and industrial contaminants. Hundreds of millions of people may have metal exposure associated with toxicity, serious health problems, and cancer occurrence. Metal exposure is found to induce oxidative stress, DNA damage and repair, and activation of multiple signaling pathways. However, molecular mechanisms of metal-induced carcinogenesis remain to be elucidated. Recent studies demonstrated that the exposure of metals such as arsenic, hexavalent chromium, cadmium, and nickel caused dysregulation of microRNAs that are implicated to play an important role in cell transformation, tumor growth and angiogenesis. This review focuses on the recent studies that show metal-induced miRNA dysregulation and underlined mechanisms in cell malignant transformation, angiogenesis and tumor growth.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / MicroRNAs / Metais / Neovascularização Patológica Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transformação Celular Neoplásica / MicroRNAs / Metais / Neovascularização Patológica Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article