Mechanism of action of glycyrrhizin against Plasmodium falciparum.
Mem Inst Oswaldo Cruz
; 116: e210084, 2021.
Article
em En
| MEDLINE
| ID: mdl-34431854
ABSTRACT
Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Glycyrrhiza
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article