[Main Approaches to Controlled Protein Degradation in the Cell].
Mol Biol (Mosk)
; 55(4): 543-561, 2021.
Article
em Ru
| MEDLINE
| ID: mdl-34432773
ABSTRACT
One of the most informative methods to study the roles of individual proteins in cell functions is based on changing their intracellular concentrations. Genetic knockouts or knockdowns are most commonly used for the purpose. However, acting directly at the level of an expressed protein is more informative or convenient to perform in some cases. This action should ideally be controlled in time and reversible. The review analyzes the current data on systems developed to achieve controlled degradation of proteins via their ubiquitination with subsequent proteasome-mediated degradation or other mechanisms.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
Idioma:
Ru
Ano de publicação:
2021
Tipo de documento:
Article