Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem Cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner Syndrome.

Gudmundsrud, Ruben; Skjånes, Tarjei H; Gilmour, Brian C; Caponio, Domenica; Lautrup, Sofie; Fang, Evandro F

Gudmundsrud, Ruben; Skjånes, Tarjei H; Gilmour, Brian C; Caponio, Domenica; Lautrup, Sofie; Fang, Evandro F.

Afiliação

Gudmundsrud R; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Skjånes TH; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Gilmour BC; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.
Caponio D; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Lautrup S; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.
Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.

Cytogenet Genome Res ; 161(6-7): 297-304, 2021.

Article em En | MEDLINE | ID: mdl-34433164

Assuntos

Envelhecimento/genética; Dano ao DNA; Mitocôndrias/genética; Mitofagia/genética; Células-Tronco/metabolismo; Síndrome de Werner/genética; Animais; Senescência Celular/genética; Humanos; Mitocôndrias/metabolismo; Telômero/genética; Telômero/metabolismo; Síndrome de Werner/metabolismo; Síndrome de Werner/patologia

Palavras-chave

Accelerated ageing; Ageing; DNA repair; Mitophagy; NAD+; Werner syndrome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Síndrome de Werner / Dano ao DNA / Envelhecimento / Mitofagia / Mitocôndrias Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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