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Organic Hyperbolic Material Assisted Illumination Nanoscopy.
Lee, Yeon Ui; Posner, Clara; Nie, Zhaoyu; Zhao, Junxiang; Li, Shilong; Bopp, Steven Edward; Wisna, Gde Bimananda Mahardika; Ha, Jeongho; Song, Chengyu; Zhang, Jin; Yang, Sui; Zhang, Xiang; Liu, Zhaowei.
Afiliação
  • Lee YU; Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  • Posner C; Department of Physics, Chungbuk National University, Cheongju, Chungbuk, 28644, South Korea.
  • Nie Z; Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  • Zhao J; Department of Mechanical Engineering, University of California, Berkeley, CA, 94720, USA.
  • Li S; Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  • Bopp SE; Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  • Wisna GBM; Materials Science and Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  • Ha J; Materials Science and Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  • Song C; Department of Electrical and Computer Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  • Zhang J; National Center for Electron Microscopy, The Molecular Foundry, One Cyclotron Road, Berkeley, CA, 94720, USA.
  • Yang S; Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
  • Zhang X; Materials Science and Engineering, School for Engineering of Matter Transport and Energy, Arizona State University, Tempe, AZ, 85287, USA.
  • Liu Z; Department of Mechanical Engineering, University of California, Berkeley, CA, 94720, USA.
Adv Sci (Weinh) ; 8(22): e2102230, 2021 11.
Article em En | MEDLINE | ID: mdl-34436815
ABSTRACT
Resolution capability of the linear structured illumination microscopy (SIM) plays a key role in its applications in physics, medicine, biology, and life science. Many advanced methodologies have been developed to extend the resolution of structured illumination by using subdiffraction-limited optical excitation patterns. However, obtaining SIM images with a resolution beyond 40 nm at visible frequency remains as an insurmountable obstacle due to the intrinsic limitation of spatial frequency bandwidth of the involved materials and the complexity of the illumination system. Here, a low-loss natural organic hyperbolic material (OHM) that can support record high spatial-frequency modes beyond 50k0 , i.e., effective refractive index larger than 50, at visible frequencies is reported. OHM-based speckle structured illumination microscopy demonstrates imaging resolution at 30 nm scales with enhanced fluorophore photostability, biocompatibility, easy to use and low cost. This study will open up a new route in super-resolution microscopy by utilizing OHM films for various applications including bioimaging and sensing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Iluminação / Nanotecnologia Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Iluminação / Nanotecnologia Idioma: En Ano de publicação: 2021 Tipo de documento: Article