Formation of Microcages from a Collagen Mimetic Peptide via Metal-Ligand Interactions.
Molecules
; 26(16)2021 Aug 12.
Article
em En
| MEDLINE
| ID: mdl-34443477
ABSTRACT
Here, the hierarchical assembly of a collagen mimetic peptide (CMP) displaying four bipyridine moieties is described. The CMP was capable of forming triple helices followed by self-assembly into disks and domes. Treatment of these disks and domes with metal ions such as Fe(II), Cu(II), Zn(II), Co(II), and Ru(III) triggered the formation of microcages, and micron-sized cup-like structures. Mechanistic studies suggest that the formation of the microcages proceeds from the disks and domes in a metal-dependent fashion. Fluorescently-labeled dextrans were encapsulated within the cages and displayed a time-dependent release using thermal conditions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Colágeno
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Materiais Biomiméticos
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Metais
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article