Stereodivergent entry to ß-branched ß-trifluoromethyl α-amino acid derivatives by sequential catalytic asymmetric reactions.
Chem Sci
; 12(30): 10233-10241, 2021 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-34447530
ABSTRACT
Currently, conventional reductive catalytic methodologies do not guarantee general access to enantioenriched ß-branched ß-trifluoromethyl α-amino acid derivatives. Herein, a one-pot approach to these important α-amino acids, grounded on the reduction - ring opening of Erlenmeyer-Plöchl azlactones, is presented. The configurations of the two chirality centers of the products are established during each of the two catalytic steps, enabling a stereodivergent process.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article