A drug candidate for Alzheimer's and Huntington's disease, PBT2, can be repurposed to render Neisseria gonorrhoeae susceptible to natural cationic antimicrobial peptides.

Jen, Freda E-C; El-Deeb, Ibrahim M; Zalucki, Yaramah M; Edwards, Jennifer L; Walker, Mark J; von Itzstein, Mark; Jennings, Michael P

Jen, Freda E-C; El-Deeb, Ibrahim M; Zalucki, Yaramah M; Edwards, Jennifer L; Walker, Mark J; von Itzstein, Mark; Jennings, Michael P.

Afiliação

Jen FE; Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
El-Deeb IM; Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Zalucki YM; Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Edwards JL; The Center for Microbial Pathogenesis, The Abigail Wexner Research Institute at Nationwide Children's Hospital and The Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Walker MJ; School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland, Australia.
von Itzstein M; Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.
Jennings MP; Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland 4222, Australia.

J Antimicrob Chemother ; 76(11): 2850-2853, 2021 10 11.

Article em En | MEDLINE | ID: mdl-34450628

Assuntos

Doença de Alzheimer; Gonorreia; Doença de Huntington; Preparações Farmacêuticas; Doença de Alzheimer/tratamento farmacológico; Antibacterianos/farmacologia; Antibacterianos/uso terapêutico; Peptídeos Catiônicos Antimicrobianos/farmacologia; Peptídeos Antimicrobianos; Gonorreia/tratamento farmacológico; Humanos; Doença de Huntington/tratamento farmacológico; Testes de Sensibilidade Microbiana; Neisseria gonorrhoeae; Proteômica

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Gonorreia / Doença de Huntington / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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