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Dual-modality optical coherence tomography and fluorescence tethered capsule endomicroscopy.
Wartak, Andreas; Kelada, Alfred K; Leon Alarcon, Paola A; Bablouzian, Ara L; Ahsen, Osman O; Gregg, Abigail L; Wei, Yuxiao; Bollavaram, Keval; Sheil, Conor J; Farewell, Edward; VanTol, Schuyler; Smith, Rachel; Grahmann, Patricia; Baillargeon, Aaron R; Gardecki, Joseph A; Tearney, Guillermo J.
Afiliação
  • Wartak A; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Kelada AK; Department of Dermatology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
  • Leon Alarcon PA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Bablouzian AL; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Ahsen OO; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Gregg AL; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Wei Y; Department of Dermatology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
  • Bollavaram K; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Sheil CJ; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Farewell E; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
  • VanTol S; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Smith R; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
  • Grahmann P; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Baillargeon AR; Department of Dermatology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
  • Gardecki JA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Tearney GJ; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Biomed Opt Express ; 12(7): 4308-4323, 2021 Jul 01.
Article em En | MEDLINE | ID: mdl-34457416
ABSTRACT
OCT tethered capsule endomicroscopy (TCE) is an emerging noninvasive diagnostic imaging technology for gastrointestinal (GI) tract disorders. OCT measures tissue reflectivity that provides morphologic image contrast, and thus is incapable of ascertaining molecular information that can be useful for improving diagnostic accuracy. Here, we introduce an extension to OCT TCE that includes a fluorescence (FL) imaging channel for attaining complementary, co-registered molecular contrast. We present the development of an OCT-FL TCE capsule and a portable, plug-and-play OCT-FL imaging system. The technology is validated in phantom experiments and feasibility is demonstrated in a methylene blue (MB)-stained swine esophageal injury model, ex vivo and in vivo.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article