Isolation and Total Synthesis of Kinenzoline, an Antitrypanosomal Linear Depsipeptide Isolated from a Marine Salileptolyngbya sp. Cyanobacterium.
J Org Chem
; 86(18): 12528-12536, 2021 09 17.
Article
em En
| MEDLINE
| ID: mdl-34463094
ABSTRACT
Kinenzoline (1), a new linear depsipeptide, was isolated from a marine Salileptolyngbya sp. cyanobacterium. Its structure was elucidated by spectroscopic analyses and degradation reactions. In addition, we achieved a total synthesis of 1 and confirmed its structure. Kinenzoline (1) showed highly selective antiproliferative activity against the causative organism of sleeping sickness, Trypanosoma brucei rhodesiense (IC50 4.5 µM), compared to normal human cells (WI-38, IC50 > 100 µM). Kinenzoline (1) is a promising lead compound for the development of new antitrypanosomal drugs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tripanossomicidas
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Tripanossomíase Africana
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Cianobactérias
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Depsipeptídeos
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Antiprotozoários
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article