GAGE mediates radio resistance in cervical cancers via the regulation of chromatin accessibility.

Nin, Dawn Sijin; Wujanto, Caryn; Tan, Tuan Zea; Lim, Diana; Damen, J Mirjam A; Wu, Kuan-Yi; Dai, Ziyu Melvin; Lee, Zheng-Wei; Idres, Shabana Binte; Leong, Yiat Horng; Jha, Sudhakar; Ng, Joseph Soon-Yau; Low, Jeffrey J H; Chang, Shih-Chung; Tan, David Shao Peng; Wu, Wei; Choo, Bok Ai; Deng, Lih-Wen

Nin, Dawn Sijin; Wujanto, Caryn; Tan, Tuan Zea; Lim, Diana; Damen, J Mirjam A; Wu, Kuan-Yi; Dai, Ziyu Melvin; Lee, Zheng-Wei; Idres, Shabana Binte; Leong, Yiat Horng; Jha, Sudhakar; Ng, Joseph Soon-Yau; Low, Jeffrey J H; Chang, Shih-Chung; Tan, David Shao Peng; Wu, Wei; Choo, Bok Ai; Deng, Lih-Wen.

Afiliação

Nin DS; Department of Biochemistry, Yong Loo Lin School of Medicine (YLLSOM), National University of Singapore (NUS), Singapore 117596, Singapore; NUS Center for Cancer Research, YLLSOM, NUS, Singapore 117599, Singapore. Electronic address: bchnsda@nus.edu.sg.
Wujanto C; Department of Radiation Oncology, National University Hospital (NUH), Singapore 119074, Singapore; National University Cancer Institute, Singapore National University Health System (NUHS), Singapore 119074, Singapore.
Tan TZ; Cancer Science Institute of Singapore, NUS, Singapore 117599, Singapore.
Lim D; Department of Pathology, NUH, Singapore 119074, Singapore; National University Cancer Institute, Singapore National University Health System (NUHS), Singapore 119074, Singapore.
Damen JMA; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht , the Netherlands.
Wu KY; Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan.
Dai ZM; Department of Biochemistry, Yong Loo Lin School of Medicine (YLLSOM), National University of Singapore (NUS), Singapore 117596, Singapore.
Lee ZW; Department of Biochemistry, Yong Loo Lin School of Medicine (YLLSOM), National University of Singapore (NUS), Singapore 117596, Singapore.
Idres SB; Department of Biochemistry, Yong Loo Lin School of Medicine (YLLSOM), National University of Singapore (NUS), Singapore 117596, Singapore.
Leong YH; Department of Radiation Oncology, National University Hospital (NUH), Singapore 119074, Singapore; National University Cancer Institute, Singapore National University Health System (NUHS), Singapore 119074, Singapore.
Jha S; Department of Biochemistry, Yong Loo Lin School of Medicine (YLLSOM), National University of Singapore (NUS), Singapore 117596, Singapore; Cancer Science Institute of Singapore, NUS, Singapore 117599, Singapore; National University Cancer Institute, Singapore National University Health System (NUHS)
Ng JS; National University Cancer Institute, Singapore National University Health System (NUHS), Singapore 119074, Singapore; Department of Obstetrics and Gynecology, YLLSOM, NUS, Singapore 119228, Singapore.
Low JJH; National University Cancer Institute, Singapore National University Health System (NUHS), Singapore 119074, Singapore; Department of Obstetrics and Gynecology, YLLSOM, NUS, Singapore 119228, Singapore.
Chang SC; Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan.
Tan DSP; Cancer Science Institute of Singapore, NUS, Singapore 117599, Singapore; National University Cancer Institute, Singapore National University Health System (NUHS), Singapore 119074, Singapore; Department of Hematology-Oncology, NUHS, Singapore 119228, Singapore; NUS Center for Cancer Research, YLLSOM
Wu W; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht , the Netherlands.
Choo BA; Department of Radiation Oncology, National University Hospital (NUH), Singapore 119074, Singapore; National University Cancer Institute, Singapore National University Health System (NUHS), Singapore 119074, Singapore.
Deng LW; Department of Biochemistry, Yong Loo Lin School of Medicine (YLLSOM), National University of Singapore (NUS), Singapore 117596, Singapore; National University Cancer Institute, Singapore National University Health System (NUHS), Singapore 119074, Singapore; NUS Center for Cancer Research, YLLSOM, NU

Cell Rep ; 36(9): 109621, 2021 08 31.

Article em En | MEDLINE | ID: mdl-34469741

Assuntos

Antígenos de Neoplasias; Montagem e Desmontagem da Cromatina; Cromatina; Histonas; Tolerância a Radiação; Neoplasias do Colo do Útero; Animais; Feminino; Humanos; Acetilação; Antígenos de Neoplasias/genética; Antígenos de Neoplasias/metabolismo; Cromatina/genética; Cromatina/metabolismo; Reparo do DNA; Regulação Neoplásica da Expressão Gênica; Células HeLa; Histona Desacetilase 1/genética; Histona Desacetilase 1/metabolismo; Histona Desacetilase 2/genética; Histona Desacetilase 2/metabolismo; Histonas/metabolismo; Proteínas de Filamentos Intermediários/genética; Proteínas de Filamentos Intermediários/metabolismo; Lisina; Camundongos Endogâmicos BALB C; Camundongos Nus; Processamento de Proteína Pós-Traducional; Tolerância a Radiação/genética; Transdução de Sinais; Neoplasias do Colo do Útero/genética; Neoplasias do Colo do Útero/metabolismo; Neoplasias do Colo do Útero/patologia; Neoplasias do Colo do Útero/radioterapia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

CT antigens; DNA damage response; DNA repair; GAGE; GAGE12; cancer testis antigens; cervical cancer; chromatin dynamics; radioresistance; radiotherapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tolerância a Radiação / Cromatina / Histonas / Neoplasias do Colo do Útero / Montagem e Desmontagem da Cromatina / Antígenos de Neoplasias Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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