Seizure Phenotype and Underlying Cellular Defects in <i>Drosophila</i> Knock-In Models of DS (R1648C) and GEFS+ (R1648H) <i>SCN1A</i> Epilepsy.

Roemmich, Alexa Joanna; Vu, Thy; Lukacsovich, Tamas; Hawkins, Charlesice; Schutte, Soleil S; O'Dowd, Diane K

Seizure Phenotype and Underlying Cellular Defects in Drosophila Knock-In Models of DS (R1648C) and GEFS+ (R1648H) SCN1A Epilepsy.

Roemmich, Alexa Joanna; Vu, Thy; Lukacsovich, Tamas; Hawkins, Charlesice; Schutte, Soleil S; O'Dowd, Diane K.

Afiliação

Roemmich AJ; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697.
Vu T; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697.
Lukacsovich T; Faculties of Medicine and Natural Sciences, Brain Research Institute, University of Zürich, CH-8057 Zürich, Switzerland.
Hawkins C; Office of Intramural Training and Education, National Institutes of Health, Bethesda, Maryland 20892.
Schutte SS; Department of Anesthesiology, University of Florida, Gainesville, Florida 32610.
O'Dowd DK; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697 dkodowd@uci.edu.

eNeuro ; 8(5)2021.

Article em En | MEDLINE | ID: mdl-34475263

Assuntos

Epilepsias Mioclônicas; Epilepsia; Animais; Drosophila; Epilepsia/genética; Neurônios GABAérgicos; Humanos; Mutação/genética; Canal de Sódio Disparado por Voltagem NAV1.1/genética; Fenótipo; Convulsões/genética

Palavras-chave

Drosophila; SCN1A; electrophysiology; epilepsy; sodium channel

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsias Mioclônicas / Epilepsia Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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