Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury.

Roth, Katherine; Yang, Zhao; Agarwal, Manisha; Liu, Wendy; Peng, Zheyun; Long, Ze; Birbeck, Johnna; Westrick, Judy; Liu, Wanqing; Petriello, Michael C

Roth, Katherine; Yang, Zhao; Agarwal, Manisha; Liu, Wendy; Peng, Zheyun; Long, Ze; Birbeck, Johnna; Westrick, Judy; Liu, Wanqing; Petriello, Michael C.

Afiliação

Roth K; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA.
Yang Z; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA.
Agarwal M; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA; Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48202, USA.
Liu W; Department of Pathology, University Hospitals, Cleveland Medical Center, Cleveland, OH 44106, USA.
Peng Z; Department of Pharmaceutical Sciences, College of Pharmacy, Wayne State University, Detroit, MI 48202, USA.
Long Z; Department of Pharmaceutical Sciences, College of Pharmacy, Wayne State University, Detroit, MI 48202, USA.
Birbeck J; Department of Chemistry, Lumigen Instrumentation Center, Wayne State University, Detroit, MI 48202, USA.
Westrick J; Department of Chemistry, Lumigen Instrumentation Center, Wayne State University, Detroit, MI 48202, USA.
Liu W; Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48202, USA; Department of Pharmaceutical Sciences, College of Pharmacy, Wayne State University, Detroit, MI 48202, USA.
Petriello MC; Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48202, USA; Department of Pharmacology, School of Medicine, Wayne State University, Detroit, MI 48202, USA. Electronic address: Michael.petriello@wayne.edu.

Environ Int ; 157: 106843, 2021 12.

Article em En | MEDLINE | ID: mdl-34479135

Assuntos

Ácidos Alcanossulfônicos; Poluentes Ambientais; Fluorocarbonos; Animais; Colesterol; Poluentes Ambientais/toxicidade; Feminino; Fluorocarbonos/toxicidade; Metabolismo dos Lipídeos; Fígado; Masculino; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

Bile acids; Cardiometabolic disease; Cholesterol; Hyperlipidemia; Liver injury; PFAS toxicity; Per- and polyfluoroalkyl substances

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Alcanossulfônicos / Poluentes Ambientais / Fluorocarbonos Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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