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The genomics of heart failure: design and rationale of the HERMES consortium.
Lumbers, R Thomas; Shah, Sonia; Lin, Honghuang; Czuba, Tomasz; Henry, Albert; Swerdlow, Daniel I; Mälarstig, Anders; Andersson, Charlotte; Verweij, Niek; Holmes, Michael V; Ärnlöv, Johan; Svensson, Per; Hemingway, Harry; Sallah, Neneh; Almgren, Peter; Aragam, Krishna G; Asselin, Geraldine; Backman, Joshua D; Biggs, Mary L; Bloom, Heather L; Boersma, Eric; Brandimarto, Jeffrey; Brown, Michael R; Brunner-La Rocca, Hans-Peter; Carey, David J; Chaffin, Mark D; Chasman, Daniel I; Chazara, Olympe; Chen, Xing; Chen, Xu; Chung, Jonathan H; Chutkow, William; Cleland, John G F; Cook, James P; de Denus, Simon; Dehghan, Abbas; Delgado, Graciela E; Denaxas, Spiros; Doney, Alexander S; Dörr, Marcus; Dudley, Samuel C; Engström, Gunnar; Esko, Tõnu; Fatemifar, Ghazaleh; Felix, Stephan B; Finan, Chris; Ford, Ian; Fougerousse, Francoise; Fouodjio, René; Ghanbari, Mohsen.
Afiliação
  • Lumbers RT; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
  • Shah S; Health Data Research UK London, University College London, London, UK.
  • Lin H; BHF Research Accelerator, University College London, London, UK.
  • Czuba T; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
  • Henry A; Institute of Cardiovascular Science, University College London, London, UK.
  • Swerdlow DI; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
  • Mälarstig A; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
  • Andersson C; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
  • Verweij N; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
  • Holmes MV; Institute of Cardiovascular Science, University College London, London, UK.
  • Ärnlöv J; Institute of Cardiovascular Science, University College London, London, UK.
  • Svensson P; Department of Medicine, Imperial College London, London, UK.
  • Hemingway H; Pfizer Worldwide Research & Development, Cambridge, MA, USA.
  • Sallah N; Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
  • Almgren P; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
  • Aragam KG; Department of Cardiology, Herlev Gentofte Hospital, Herlev, Denmark.
  • Asselin G; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Backman JD; Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
  • Biggs ML; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.
  • Bloom HL; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.
  • Boersma E; Department of Neurobiology, Care Sciences and Society/Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
  • Brandimarto J; School of Health and Social Sciences, Dalarna University, Falun, Sweden.
  • Brown MR; Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.
  • Brunner-La Rocca HP; Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
  • Carey DJ; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
  • Chaffin MD; Health Data Research UK London, University College London, London, UK.
  • Chasman DI; The National Institute for Health Research, University College London Hospitals Biomedical Research Centre, University College London, London, UK.
  • Chazara O; Institute of Health Informatics, University College London, Gower St, London, WC1E 7HB, UK.
  • Chen X; Health Data Research UK London, University College London, London, UK.
  • Chen X; UCL Genetics Institute, University College London, London, UK.
  • Chung JH; Department of Clinical Sciences, Lund University, Malmö, Sweden.
  • Chutkow W; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Cleland JGF; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Cook JP; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
  • de Denus S; Montreal Heart Institute, Montreal, Quebec, Canada.
  • Dehghan A; Regeneron Genetics Center, Tarrytown, NY, USA.
  • Delgado GE; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Denaxas S; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
  • Doney AS; Division of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA.
  • Dörr M; Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Dudley SC; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Engström G; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Esko T; Maastricht University Medical Center, Maastricht, The Netherlands.
  • Fatemifar G; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA.
  • Felix SB; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Finan C; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Ford I; Harvard Medical School, Boston, MA, USA.
  • Fougerousse F; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Fouodjio R; Pfizer Worldwide Research & Development, Cambridge, MA, USA.
  • Ghanbari M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
ESC Heart Fail ; 8(6): 5531-5541, 2021 12.
Article em En | MEDLINE | ID: mdl-34480422
AIMS: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. METHODS AND RESULTS: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34-90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01-0.05) at P < 5 × 10-8 under an additive genetic model. CONCLUSIONS: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudo de Associação Genômica Ampla / Insuficiência Cardíaca Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudo de Associação Genômica Ampla / Insuficiência Cardíaca Tipo de estudo: Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article