Transient Dexamethasone Loading Induces Prolonged Hyperglycemia in Male Mice With Histone Acetylation in Dpp-4 Promoter.

Uto, Asuka; Miyashita, Kazutoshi; Endo, Sho; Sato, Masaaki; Ryuzaki, Masaki; Kinouchi, Kenichiro; Mitsuishi, Masanori; Meguro, Shu; Itoh, Hiroshi

Uto, Asuka; Miyashita, Kazutoshi; Endo, Sho; Sato, Masaaki; Ryuzaki, Masaki; Kinouchi, Kenichiro; Mitsuishi, Masanori; Meguro, Shu; Itoh, Hiroshi.

Afiliação

Uto A; Division of Endocrinology, Metabolism and Nephrology, Keio University, School of Medicine, Tokyo, 160-8582, Japan.
Miyashita K; Division of Endocrinology, Metabolism and Nephrology, Keio University, School of Medicine, Tokyo, 160-8582, Japan.
Endo S; Division of Endocrinology, Metabolism and Nephrology, Keio University, School of Medicine, Tokyo, 160-8582, Japan.
Sato M; Division of Endocrinology, Metabolism and Nephrology, Keio University, School of Medicine, Tokyo, 160-8582, Japan.
Ryuzaki M; Division of Endocrinology, Metabolism and Nephrology, Keio University, School of Medicine, Tokyo, 160-8582, Japan.
Kinouchi K; Division of Endocrinology, Metabolism and Nephrology, Keio University, School of Medicine, Tokyo, 160-8582, Japan.
Mitsuishi M; Division of Endocrinology, Metabolism and Nephrology, Keio University, School of Medicine, Tokyo, 160-8582, Japan.
Meguro S; Division of Endocrinology, Metabolism and Nephrology, Keio University, School of Medicine, Tokyo, 160-8582, Japan.
Itoh H; Division of Endocrinology, Metabolism and Nephrology, Keio University, School of Medicine, Tokyo, 160-8582, Japan.

Endocrinology ; 162(12)2021 12 01.

Article em En | MEDLINE | ID: mdl-34480538

Assuntos

Dexametasona/farmacologia; Dipeptidil Peptidase 4/genética; Hiperglicemia/patologia; Regiões Promotoras Genéticas/efeitos dos fármacos; Acetilação/efeitos dos fármacos; Animais; Células Cultivadas; Estudos de Coortes; Dexametasona/administração & dosagem; Dipeptidil Peptidase 4/efeitos dos fármacos; Dipeptidil Peptidase 4/metabolismo; Progressão da Doença; Relação Dose-Resposta a Droga; Epigênese Genética/efeitos dos fármacos; Histonas/efeitos dos fármacos; Histonas/metabolismo; Humanos; Hiperglicemia/genética; Hiperglicemia/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Processamento de Proteína Pós-Traducional/efeitos dos fármacos; Estudos Retrospectivos; Fatores de Tempo

Palavras-chave

DPP-4; GLP-1; dexamethasone; glucocorticoid induced hyperglycemia; histone acetylation; memory phenomenon

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dexametasona / Regiões Promotoras Genéticas / Dipeptidil Peptidase 4 / Hiperglicemia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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