Intracranial effect of osimertinib in relapsed <i>EGFR</i>-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study.

Eide, Inger Johanne Zwicky; Grut, Harald; Helland, Åslaug; Ekman, Simon; Sørensen, Jens Benn; Hansen, Karin Holmskov; Grønberg, Bjørn Henning; Cicenas, Saulius; Koivunen, Jussi Pekka; Mellemgaard, Anders; Brustugun, Odd Terje

Intracranial effect of osimertinib in relapsed EGFR-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study.

Eide, Inger Johanne Zwicky; Grut, Harald; Helland, Åslaug; Ekman, Simon; Sørensen, Jens Benn; Hansen, Karin Holmskov; Grønberg, Bjørn Henning; Cicenas, Saulius; Koivunen, Jussi Pekka; Mellemgaard, Anders; Brustugun, Odd Terje.

Afiliação

Eide IJZ; Section of Oncology, Vestre Viken Hospital Trust, Drammen, Norway.
Grut H; Department of Cancer Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Helland Å; Department of Clinical Medicine, University of Oslo, Oslo, Norway.
Ekman S; Department of Radiology, Vestre Viken Hospital Trust, Drammen, Norway.
Sørensen JB; Department of Cancer Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
Hansen KH; Department of Clinical Medicine, University of Oslo, Oslo, Norway.
Grønberg BH; Department of Oncology, Oslo University Hospital, Oslo, Norway.
Cicenas S; Thoracic Oncology Center, Karolinska University Hospital/Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Koivunen JP; Rigshospitalet, Copenhagen, Denmark.
Mellemgaard A; Odense University Hospital, Odense, Denmark.
Brustugun OT; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Acta Oncol ; 60(12): 1565-1571, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34486915

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Acrilamidas; Compostos de Anilina; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Receptores ErbB/genética; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Mutação; Inibidores de Proteínas Quinases/uso terapêutico

Palavras-chave

EGFR; T790M; brain metastases; non-small cell lung cancer; osimertinib

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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