Your browser doesn't support javascript.
loading
Blood pressure, executive function, and network connectivity in middle-aged adults at risk of dementia in late life.
Jenkins, Lisanne M; Kogan, Alexandr; Malinab, Matthew; Ingo, Carson; Sedaghat, Sanaz; Bryan, Nick R; Yaffe, Kristine; Parrish, Todd B; Nemeth, Alexander J; Lloyd-Jones, Donald M; Launer, Lenore J; Wang, Lei; Sorond, Farzaneh.
Afiliação
  • Jenkins LM; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; lisanne.jenkins@northwestern.edu.
  • Kogan A; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
  • Malinab M; Faculty of Applied Sciences, Simon Fraser University, Burnaby, BC, Canada, V5A 1S6.
  • Ingo C; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
  • Sedaghat S; Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
  • Bryan NR; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
  • Yaffe K; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
  • Parrish TB; Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19103.
  • Nemeth AJ; Weill Institute for Neurosciences, University of California, San Francisco, CA 94121.
  • Lloyd-Jones DM; Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
  • Launer LJ; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
  • Wang L; McCormick School of Engineering, Northwestern University, Chicago, IL 60208.
  • Sorond F; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Proc Natl Acad Sci U S A ; 118(37)2021 09 14.
Article em En | MEDLINE | ID: mdl-34493658
Midlife blood pressure is associated with structural brain changes, cognitive decline, and dementia in late life. However, the relationship between early adulthood blood pressure exposure, brain structure and function, and cognitive performance in midlife is not known. A better understanding of these relationships in the preclinical stage may advance our mechanistic understanding of vascular contributions to late-life cognitive decline and dementia and may provide early therapeutic targets. To identify resting-state functional connectivity of executive control networks (ECNs), a group independent components analysis was performed of functional MRI scans of 600 individuals from the Coronary Artery Risk Development in Young Adults longitudinal cohort study, with cumulative systolic blood pressure (cSBP) measured at nine visits over the preceding 30 y. Dual regression analysis investigated performance-related connectivity of ECNs in 578 individuals (mean age 55.5 ± 3.6 y, 323 female, 243 Black) with data from the Stroop color-word task of executive function. Greater connectivity of a left ECN to the bilateral anterior gyrus rectus, right posterior orbitofrontal cortex, and nucleus accumbens was associated with better executive control performance on the Stroop. Mediation analyses showed that while the relationship between cSBP and Stroop performance was mediated by white matter hyperintensities (WMH), resting-state connectivity of the ECN mediated the relationship between WMH and executive function. Increased connectivity of the left ECN to regions involved in reward processing appears to compensate for the deleterious effects of WMH on executive function in individuals across the burden of cumulative systolic blood pressure exposure in midlife.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Encéfalo / Demência / Função Executiva / Disfunção Cognitiva / Substância Branca / Vias Neurais Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Encéfalo / Demência / Função Executiva / Disfunção Cognitiva / Substância Branca / Vias Neurais Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Ano de publicação: 2021 Tipo de documento: Article