Five new quinoline alkaloids from Sauropus hirsutus Beille and their cytotoxicity.
Nat Prod Res
; 37(3): 361-368, 2023 Feb.
Article
em En
| MEDLINE
| ID: mdl-34507517
ABSTRACT
Chemical investigation of the whole plant of Sauropus hirsutus Beille led to the isolation of eight quinolines and two known flavonoids. Furthermore, five quinolines were new, two were reported in plant for the first time and one was known. Cytotoxicity evaluation against cholangiocarcinoma, KKU-M156, showed that the most active compound was 4-hydroxy-6-methoxy-7,8-methylenedioxyquinaldine (IC50 20.54 ± 6.82 µM) which was a little more active than the cisplatin standard (IC50 24.39 ± 1.14 µM).
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Neoplasias dos Ductos Biliares
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Alcaloides
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article