Atherosclerosis and Cardiovascular Diseases in Progeroid Syndromes.
J Atheroscler Thromb
; 29(4): 439-447, 2022 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-34511576
ABSTRACT
Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the representative genetic progeroid syndromes and have been widely studied in the field of aging research. HGPS is a pediatric disease in which premature aging symptoms appear in early childhood, and death occurs at an average age of 14.5 years, mainly due to cardiovascular disease (CVD). Conversely, WS patients exhibit accelerated aging phenotypes after puberty and die in their 50s due to CVD and malignant tumors. Both diseases are models of human aging, leading to a better understanding of the aging-associated development of CVD. In this review, we discuss the pathogenesis and treatment of atherosclerotic diseases presented by both progeroid syndromes with the latest findings.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progéria
/
Síndrome de Werner
/
Doenças Cardiovasculares
/
Aterosclerose
Tipo de estudo:
Prognostic_studies
Limite:
Child, preschool
/
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article