Role of mTOR Signaling for Tubular Function and Disease.
Physiology (Bethesda)
; 36(6): 350-358, 2021 11 01.
Article
em En
| MEDLINE
| ID: mdl-34514872
ABSTRACT
The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton, and survival. Recent studies have identified the importance of these complexes for transport regulation of ions and nutrients along the entire nephron. First reports could link altered activity of these complexes to certain disease entities, i.e. diabetic nephropathy, acute kidney injury or hyperkalemia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sirolimo
/
Serina-Treonina Quinases TOR
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article