Viral Manipulation of a Mechanoresponsive Signaling Axis Disassembles Processing Bodies.
Mol Cell Biol
; 41(11): e0039921, 2021 10 26.
Article
em En
| MEDLINE
| ID: mdl-34516278
ABSTRACT
Processing bodies (PBs) are ribonucleoprotein granules important for cytokine mRNA decay that are targeted for disassembly by many viruses. Kaposi's sarcoma-associated herpesvirus is the etiological agent of the inflammatory endothelial cancer, Kaposi's sarcoma, and a PB-regulating virus. The virus encodes kaposin B (KapB), which induces actin stress fibers (SFs) and cell spindling as well as PB disassembly. We now show that KapB-mediated PB disassembly requires actin rearrangements, RhoA effectors, and the mechanoresponsive transcription activator, YAP. Moreover, ectopic expression of active YAP or exposure of ECs to mechanical forces caused PB disassembly in the absence of KapB. We propose that the viral protein KapB activates a mechanoresponsive signaling axis and links changes in cell shape and cytoskeletal structures to enhanced inflammatory molecule expression using PB disassembly. Our work implies that cytoskeletal changes in other pathologies may similarly impact the inflammatory environment.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
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Transformação Celular Neoplásica
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Proteína rhoA de Ligação ao GTP
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Mecanotransdução Celular
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Corpos de Processamento
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Proteínas de Sinalização YAP
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article