Canonical Wnt: a safeguard and threat for erythropoiesis.
Blood Adv
; 5(18): 3726-3735, 2021 09 28.
Article
em En
| MEDLINE
| ID: mdl-34516644
ABSTRACT
Myeloid dysplastic syndrome (MDS) reflects a preleukemic bone marrow (BM) disorder with limited treatment options and poor disease survival. As only a minority of MDS patients are eligible for curative hematopoietic stem cell transplantation, there is an urgent need to develop alternative treatment options. Chronic activation of Wnt/ß-catenin has been implicated to underlie MDS formation and recently assigned to drive MDS transformation to acute myeloid leukemia. Wnt/ß-catenin signaling therefore may harbor a pharmaceutical target to treat MDS and/or prevent leukemia formation. However, targeting the Wnt/ß-catenin pathway will also affect healthy hematopoiesis in MDS patients. The control of Wnt/ß-catenin in healthy hematopoiesis is poorly understood. Whereas Wnt/ß-catenin is dispensable for steady-state erythropoiesis, its activity is essential for stress erythropoiesis in response to BM injury and anemia. Manipulation of Wnt/ß-catenin signaling in MDS may therefore deregulate stress erythropoiesis and even increase anemia severity. Here, we provide a comprehensive overview of the most recent and established insights in the field to acquire more insight into the control of Wnt/ß-catenin signaling in healthy and inefficient erythropoiesis as seen in MDS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes Mielodisplásicas
/
Leucemia Mieloide Aguda
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article