Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1ß, TNF-&#945;, and iNOS upregulation.

Wang, Tong; Sun, Qi; Yang, Jinhan; Wang, Gaoyang; Zhao, Fenghong; Chen, Yuhua; Jin, Yaping

Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1ß, TNF-α, and iNOS upregulation.

Wang, Tong; Sun, Qi; Yang, Jinhan; Wang, Gaoyang; Zhao, Fenghong; Chen, Yuhua; Jin, Yaping.

Afiliação

Wang T; Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China.
Sun Q; Department of Child and Adolescent Health, China Medical University, Shenyang, China.
Yang J; Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China.
Wang G; Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China.
Zhao F; Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China.
Chen Y; Department of Developmental Biology, Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, China.
Jin Y; Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China. Electronic address: ypjin@cmu.edu.cn.

Food Chem Toxicol ; 157: 112550, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34517076

Assuntos

Astrócitos/efeitos dos fármacos; Etilenocloroidrina/farmacologia; Interleucina-1beta/metabolismo; Microglia/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Animais; Astrócitos/metabolismo; Western Blotting; Polaridade Celular/efeitos dos fármacos; Imunofluorescência; Microglia/efeitos dos fármacos; Ratos; Ratos Wistar; Espécies Reativas de Oxigênio/metabolismo; Reação em Cadeia da Polimerase em Tempo Real; Transdução de Sinais/efeitos dos fármacos; Regulação para Cima/efeitos dos fármacos

Palavras-chave

1,2-Dichloroethane; 2-Chloroethanol; Microglia polarization; Reactive astrocytes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Astrócitos / Fator de Necrose Tumoral alfa / Microglia / Óxido Nítrico Sintase Tipo II / Etilenocloroidrina / Interleucina-1beta Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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