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Genome-Wide Linkage and Association Study of Childhood Gender Nonconformity in Males.
Sanders, Alan R; Beecham, Gary W; Guo, Shengru; Dawood, Khytam; Rieger, Gerulf; Krishnappa, Ritesha S; Kolundzija, Alana B; Bailey, J Michael; Martin, Eden R.
Afiliação
  • Sanders AR; Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem Research Institute, 1001 University Place, Evanston, IL, 60201, USA. alan.sanders.md@gmail.com.
  • Beecham GW; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA. alan.sanders.md@gmail.com.
  • Guo S; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Dawood K; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Rieger G; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
  • Krishnappa RS; Department of Psychology, Pennsylvania State University, University Park, PA, USA.
  • Kolundzija AB; Department of Psychology, University of Essex, Colchester, UK.
  • Bailey JM; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Elmhurst, NY, USA.
  • Martin ER; Collective Impact, Washington, DC, USA.
Arch Sex Behav ; 50(8): 3377-3383, 2021 11.
Article em En | MEDLINE | ID: mdl-34518958
Male sexual orientation is influenced by environmental and complex genetic factors. Childhood gender nonconformity (CGN) is one of the strongest correlates of homosexuality with substantial familiality. We studied brothers in families with two or more homosexual brothers (409 concordant sibling pairs in 384 families, as well as their heterosexual brothers), who self-recalled their CGN. To map loci for CGN, we conducted a genome-wide linkage scan (GWLS) using SNP genotypes. The strongest linkage peaks, each with significant or suggestive two-point LOD scores and multipoint LOD score support, were on chromosomes 5q31 (maximum two-point LOD = 4.45), 6q12 (maximum two-point LOD = 3.64), 7q33 (maximum two-point LOD = 3.09), and 8q24 (maximum two-point LOD = 3.67), with the latter not overlapping with previously reported strongest linkage region for male sexual orientation on pericentromeric chromosome 8. Family-based association analyses were used to identify associated variants in the linkage regions, with a cluster of SNPs (minimum association p = 1.3 × 10-8) found at the 5q31 linkage peak. Genome-wide, clusters of multiple SNPs in the 10-6 to 10-8 p-value range were found at chromosomes 5p13, 5q31, 7q32, 8p22, and 10q23, highlighting glutamate-related genes. This is the first reported GWLS and genome-wide association study on CGN. Further increasing genetic knowledge about CGN and its relationships to male sexual orientation should help advance our understanding of the biology of these associated traits.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudo de Associação Genômica Ampla / Identidade de Gênero Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estudo de Associação Genômica Ampla / Identidade de Gênero Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article