Peptidylarginine deiminases 4 as a promising target in drug discovery.
Eur J Med Chem
; 226: 113840, 2021 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-34520958
ABSTRACT
Peptidylarginine deaminase 4 (PAD4) is a crucial post-translational modifying enzyme catalyzing the conversion of arginine into citrulline residues, and mediating the formation of neutrophil extracellular traps (NETs). PAD4 plays a vital role in the occurrence and development of cardiovascular diseases, autoimmune diseases, and various tumors. Therefore, PAD4 is considered as a promising drug target for disease diagnosis and treatment. More and more efforts are devoted to developing highly efficient and selective PAD4 inhibitors via high-throughput screening, structure-based drug design and structure-activity relationship study. This article outlined the physiological and pathological functions of PAD4, and corresponding representative small molecule inhibitors reported in recent years.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores Enzimáticos
/
Descoberta de Drogas
/
Proteína-Arginina Desiminase do Tipo 4
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article