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Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy.
Dou, Wei-Tao; Xu, Fugui; Xu, Chen-Xi; Gao, Jie; Ru, Hong-Bo; Luan, Xiangfeng; Zhang, Jiacheng; Zhu, Ling; Sedgwick, Adam C; Chen, Guo-Rong; Zang, Yi; James, Tony D; Tian, He; Li, Jia; Mai, Yiyong; He, Xiao-Peng.
Afiliação
  • Dou WT; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East Chin
  • Xu F; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University 800 Dongchuan RD Shanghai 200240 P. R. China mai@sjtu.edu.cn.
  • Xu CX; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East Chin
  • Gao J; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 189 Guo Shoujing Rd. Shanghai 201203 P. R. China jli@simm.ac.cn.
  • Ru HB; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East Chin
  • Luan X; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 189 Guo Shoujing Rd. Shanghai 201203 P. R. China jli@simm.ac.cn.
  • Zhang J; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 189 Guo Shoujing Rd. Shanghai 201203 P. R. China jli@simm.ac.cn.
  • Zhu L; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University 800 Dongchuan RD Shanghai 200240 P. R. China mai@sjtu.edu.cn.
  • Sedgwick AC; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University 800 Dongchuan RD Shanghai 200240 P. R. China mai@sjtu.edu.cn.
  • Chen GR; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East Chin
  • Zang Y; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 189 Guo Shoujing Rd. Shanghai 201203 P. R. China jli@simm.ac.cn.
  • James TD; Department of Chemistry, The University of Texas at Austin Austin Texas 78712-1224 USA.
  • Tian H; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East Chin
  • Li J; National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences 189 Guo Shoujing Rd. Shanghai 201203 P. R. China jli@simm.ac.cn.
  • Mai Y; Department of Chemistry, University of Bath Bath BA2 7AY UK.
  • He XP; School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang 453007 China.
Chem Sci ; 12(33): 11089-11097, 2021 Aug 25.
Article em En | MEDLINE | ID: mdl-34522306
ABSTRACT
Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αvß3 integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged αvß3 integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article